| Date | Opponent | Result | Record | Points | Assists | Rebounds |
|---|---|---|---|---|---|---|
| Oct 20, 2021 | Chicago Bulls (0-0) | scheduled | 0-0 | Little Caesars Arena | ||
| Oct 23, 2021 | @ Chicago Bulls (0-0) | scheduled | 0-0 | United Center | ||
| Oct 25, 2021 | @ Atlanta Hawks (0-0) | scheduled | 0-0 | State Farm Arena | ||
| Oct 28, 2021 | @ Philadelphia 76ers (0-0) | scheduled | 0-0 | Wells Fargo Center | ||
| Oct 30, 2021 | Orlando Magic (0-0) | scheduled | 0-0 | Little Caesars Arena | ||
| Oct 31, 2021 | @ Brooklyn Nets (0-0) | scheduled | 0-0 | Barclays Center | ||
| Nov 2, 2021 | Milwaukee Bucks (0-0) | scheduled | 0-0 | Little Caesars Arena | ||
| Nov 4, 2021 | Philadelphia 76ers (0-0) | scheduled | 0-0 | Little Caesars Arena | ||
| Nov 5, 2021 | Brooklyn Nets (0-0) | scheduled | 0-0 | Little Caesars Arena | ||
| Nov 10, 2021 | @ Houston Rockets (0-0) | scheduled | 0-0 | Toyota Center | ||
| Nov 12, 2021 | @ Cleveland Cavaliers (0-0) | scheduled | 0-0 | Rocket Mortgage FieldHouse | ||
| Nov 13, 2021 | @ Toronto Raptors (0-0) | scheduled | 0-0 | Scotiabank Arena | ||
| Nov 15, 2021 | Sacramento Kings (0-0) | scheduled | 0-0 | Little Caesars Arena | ||
| Nov 17, 2021 | Indiana Pacers (0-0) | scheduled | 0-0 | Little Caesars Arena | ||
| Nov 19, 2021 | Golden State Warriors (0-0) | scheduled | 0-0 | Little Caesars Arena | ||
| Nov 21, 2021 | Los Angeles Lakers (0-0) | scheduled | 0-0 | Little Caesars Arena | ||
| Nov 23, 2021 | Miami Heat (0-0) | scheduled | 0-0 | Little Caesars Arena | ||
| Nov 24, 2021 | @ Milwaukee Bucks (0-0) | scheduled | 0-0 | Fiserv Forum | ||
| Nov 26, 2021 | @ Los Angeles Clippers (0-0) | scheduled | 0-0 | Staples Center | ||
| Nov 28, 2021 | @ Los Angeles Lakers (0-0) | scheduled | 0-0 | Staples Center | ||
| Nov 30, 2021 | @ Portland Trail Blazers (0-0) | scheduled | 0-0 | Moda Center | ||
| Dec 2, 2021 | @ Phoenix Suns (0-0) | scheduled | 0-0 | Footprint Center | ||
| Dec 6, 2021 | Oklahoma City Thunder (0-0) | scheduled | 0-0 | Little Caesars Arena | ||
| Dec 8, 2021 | Washington Wizards (0-0) | scheduled | 0-0 | Little Caesars Arena | ||
| Dec 10, 2021 | @ New Orleans Pelicans (0-0) | scheduled | 0-0 | Smoothie King Center | ||
| Dec 12, 2021 | Brooklyn Nets (0-0) | scheduled | 0-0 | Little Caesars Arena | ||
| Dec 14, 2021 | @ Chicago Bulls (0-0) | scheduled | 0-0 | United Center | ||
| Dec 16, 2021 | @ Indiana Pacers (0-0) | scheduled | 0-0 | Gainbridge Fieldhouse | ||
| Dec 18, 2021 | Houston Rockets (0-0) | scheduled | 0-0 | Little Caesars Arena | ||
| Dec 19, 2021 | Miami Heat (0-0) | scheduled | 0-0 | Little Caesars Arena | ||
| Dec 21, 2021 | @ New York Knicks (0-0) | scheduled | 0-0 | Madison Square Garden | ||
| Dec 23, 2021 | @ Miami Heat (0-0) | scheduled | 0-0 | FTX Arena | ||
| Dec 26, 2021 | @ San Antonio Spurs (0-0) | scheduled | 0-0 | AT&T Center | ||
| Dec 29, 2021 | New York Knicks (0-0) | scheduled | 0-0 | Little Caesars Arena | ||
| Jan 1, 2022 | San Antonio Spurs (0-0) | scheduled | 0-0 | Little Caesars Arena | ||
| Jan 3, 2022 | @ Milwaukee Bucks (0-0) | scheduled | 0-0 | Fiserv Forum | ||
| Jan 5, 2022 | @ Charlotte Hornets (0-0) | scheduled | 0-0 | Spectrum Center | ||
| Jan 6, 2022 | @ Memphis Grizzlies (0-0) | scheduled | 0-0 | FedExForum | ||
| Jan 8, 2022 | Orlando Magic (0-0) | scheduled | 0-0 | Little Caesars Arena | ||
| Jan 10, 2022 | Utah Jazz (0-0) | scheduled | 0-0 | Little Caesars Arena | ||
| Jan 12, 2022 | Phoenix Suns (0-0) | scheduled | 0-0 | Little Caesars Arena | ||
| Jan 14, 2022 | Toronto Raptors (0-0) | scheduled | 0-0 | Little Caesars Arena | ||
| Jan 18, 2022 | @ Golden State Warriors (0-0) | scheduled | 0-0 | Chase Center | ||
| Jan 19, 2022 | @ Sacramento Kings (0-0) | scheduled | 0-0 | Golden 1 Center | ||
| Jan 21, 2022 | @ Utah Jazz (0-0) | scheduled | 0-0 | Vivint Arena | ||
| Jan 23, 2022 | @ Denver Nuggets (0-0) | scheduled | 0-0 | Ball Arena | ||
| Jan 25, 2022 | Denver Nuggets (0-0) | scheduled | 0-0 | Little Caesars Arena | ||
| Jan 28, 2022 | @ Orlando Magic (0-0) | scheduled | 0-0 | Amway Center | ||
| Jan 30, 2022 | Cleveland Cavaliers (0-0) | scheduled | 0-0 | Little Caesars Arena | ||
| Feb 1, 2022 | New Orleans Pelicans (0-0) | scheduled | 0-0 | Little Caesars Arena | ||
| Feb 3, 2022 | Minnesota Timberwolves (0-0) | scheduled | 0-0 | Little Caesars Arena | ||
| Feb 4, 2022 | Boston Celtics (0-0) | scheduled | 0-0 | Little Caesars Arena | ||
| Feb 6, 2022 | @ Minnesota Timberwolves (0-0) | scheduled | 0-0 | Target Center | ||
| Feb 8, 2022 | @ Dallas Mavericks (0-0) | scheduled | 0-0 | American Airlines Center | ||
| Feb 10, 2022 | Memphis Grizzlies (0-0) | scheduled | 0-0 | Little Caesars Arena | ||
| Feb 11, 2022 | Charlotte Hornets (0-0) | scheduled | 0-0 | Little Caesars Arena | ||
| Feb 14, 2022 | @ Washington Wizards (0-0) | scheduled | 0-0 | Capital One Arena | ||
| Feb 16, 2022 | @ Boston Celtics (0-0) | scheduled | 0-0 | TD Garden | ||
| Feb 24, 2022 | Cleveland Cavaliers (0-0) | scheduled | 0-0 | Little Caesars Arena | ||
| Feb 26, 2022 | Boston Celtics (0-0) | scheduled | 0-0 | Little Caesars Arena | ||
| Feb 27, 2022 | @ Charlotte Hornets (0-0) | scheduled | 0-0 | Spectrum Center | ||
| Mar 1, 2022 | @ Washington Wizards (0-0) | scheduled | 0-0 | Capital One Arena | ||
| Mar 3, 2022 | @ Toronto Raptors (0-0) | scheduled | 0-0 | Scotiabank Arena | ||
| Mar 4, 2022 | Indiana Pacers (0-0) | scheduled | 0-0 | Little Caesars Arena | ||
| Mar 7, 2022 | Atlanta Hawks (0-0) | scheduled | 0-0 | Little Caesars Arena | ||
| Mar 9, 2022 | Chicago Bulls (0-0) | scheduled | 0-0 | Little Caesars Arena | ||
| Mar 11, 2022 | @ Boston Celtics (0-0) | scheduled | 0-0 | TD Garden | ||
| Mar 13, 2022 | Los Angeles Clippers (0-0) | scheduled | 0-0 | Little Caesars Arena | ||
| Mar 15, 2022 | @ Miami Heat (0-0) | scheduled | 0-0 | FTX Arena | ||
| Mar 17, 2022 | @ Orlando Magic (0-0) | scheduled | 0-0 | Amway Center | ||
| Mar 19, 2022 | @ Cleveland Cavaliers (0-0) | scheduled | 0-0 | Rocket Mortgage FieldHouse | ||
| Mar 21, 2022 | Portland Trail Blazers (0-0) | scheduled | 0-0 | Little Caesars Arena | ||
| Mar 23, 2022 | Atlanta Hawks (0-0) | scheduled | 0-0 | Little Caesars Arena | ||
| Mar 25, 2022 | Washington Wizards (0-0) | scheduled | 0-0 | Little Caesars Arena | ||
| Mar 27, 2022 | New York Knicks (0-0) | scheduled | 0-0 | Little Caesars Arena | ||
| Mar 29, 2022 | @ Brooklyn Nets (0-0) | scheduled | 0-0 | Barclays Center | ||
| Mar 31, 2022 | Philadelphia 76ers (0-0) | scheduled | 0-0 | Little Caesars Arena | ||
| Apr 1, 2022 | @ Oklahoma City Thunder (0-0) | scheduled | 0-0 | Paycom Center | ||
| Apr 3, 2022 | @ Indiana Pacers (0-0) | scheduled | 0-0 | Gainbridge Fieldhouse | ||
| Apr 6, 2022 | Dallas Mavericks (0-0) | scheduled | 0-0 | Little Caesars Arena | ||
| Apr 8, 2022 | Milwaukee Bucks (0-0) | scheduled | 0-0 | Little Caesars Arena | ||
| Apr 10, 2022 | @ Philadelphia 76ers (0-0) | scheduled | 0-0 | Wells Fargo Center | ||